DIURETIC ACTION OF METOLAZONE IN DOGS

Diuretic action of garlic extract in anaesthetised normotensive dogs.

Intravenous administration of garlic extract (25.9 mg/kg body weight), significantly increases urinary output in dogs, whjch was also found to be dose dependent. The pH of urine was not altered after the administration of garlic extract. Effect of intravenous administration of Furosemide (1.0 mg/kg b. wt.) was also observed for control comparison. It was found that the garlic in high doses (54....

Synergistic action of metolazone with "loop" diuretics.

Features of the brachydactyly in this family were similar to those described by Vidal,4 and the variation in severity among family members has been reported.5 The association of the condition with colorectal cancer may have been due to chance or may be a true syndrome, permitting identification of patients at risk for colorectal neoplasia. We should be interested to hear from others who may hav...

Ethacrynic Acid: Effectiveness and Mode of Diuretic Action in Man.

ETHACRYNIC ACID is an unsaturated ketone derivative of phenoxyacetic acid* chemically different from other known diuretic agents.' Compounds of this general class have a significant ability to bind sulfhydryl groups in vitro. Ethacrynic acid was shown by Baer and associates2 to be highly effective as a diuretic in the dog, but not in the rat. A preliminary report from this laboratory indicated ...

A Study of the Diuretic Action of Acid Producing Salts.

Studies on anti-diuretic action of protein hydrolysate.

Intravenous transfusion is resorted to in various conditions of malnutrition, hypoproteinaemia and in surgery requiring intravenous alimentation (Elman, 1952; Levy and Siller, 1942; Krishnan, 1944). Being a preparation derived from proteins, several tests for its preparation, freedom from toxicity, and antigenic reactions are laid down in the pharmacopoeia (cf. Basu, Bose and Sen, 1946; U. S. P...